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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury

Fig. 1

ω-3 PUFA supplementation improves neurological function, brain edema, and BBB permeability after TBI. a ω-3 PUFA supplementation improved neurological functions 3 days after TBI (10.69 ± 0.48 vs. 12.14 ± 0.52, p < 0.05). b Rats in the TBI + ω-3 PUFA group showed significantly improved rotarod performances than rats in the TBI groups from day 7 after TBI. c ω-3 PUFA supplementation decreased brain water content 3 days after TBI (81.54 ± 0.57% vs. 82.87 ± 0.73%, p < 0.05). d A schematic of a brain section after TBI. Areas in red refer to lesioned sites and areas in blue refer to sample points. e The TBI group had more Evans blue dye extravasation in the cortex 3 days after TBI compared with the sham group (p < 0.05). Compared with the TBI group, the TBI + ω-3 PUFA group had significantly decreased Evans blue dye extravasation of (p < 0.05). Representative photos of Evans blue dye extravasation in the experimental groups. Values are expressed as mean ± standard deviation (n = 6 per group). N.S., p > 0.05, *p < 0.05, **p < 0.01

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