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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury

Fig. 4

ω-3 PUFA supplementation inhibits HMGB1 expression in lesioned cortices 3 days after TBI. Double staining was used to assessneurons (NeuN+), microglia (Iba-1+), and astrocytes (GFAP+) in the lesioned cortex. a TBI enhanced the expression of HMGB1 in neurons, which was significantly decreased by ω-3 PUFA supplementation. Representative photomicrographs of HMGB1-positive neurons are shown. b TBI enhanced the expression of HMGB1 in microglia, which was significantly decreased by ω-3 PUFA supplementation. Representative photomicrographs of HMGB1-positive microglias are shown. c ω-3 PUFA supplementation had no obvious effect on the expression of HMGB1 in astrocytes. Representative photomicrographs of HMGB1-positive astrocytes are shown. Scale bars = 50 μm

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Journal of Neuroinflammation

ISSN: 1742-2094