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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury

Fig. 6

ω-3 PUFA supplementation elevates SIRT1 expression and deacetylase activity in lesioned cortices 3 days after TBI. a SIRT1 immunoreactivity in both neurons and microglias from lesioned cortices was significantly increased by ω-3 PUFA supplementation (2.92 ± 0.52 vs. 1.86 ± 0.29, p < 0.05). b SIRT1 levels were also upregulated after ω-3 PUFA supplementation (p < 0.05). c The NAD+/NADH ratio was measured to detect SIRT1 activity. Treatment with ω-3 PUFA significantly increased the NAD+/NADH ratio (p < 0.05). Values are expressed as mean ± standard deviation (n = 6 per group). N.S., p > 0.05, *p < 0.05, **p < 0.01. Scale bars = 50 μm

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