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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis

Fig. 8

Immunofluorescence showing ICAM-1 and P-selectin expression patterns in brain vasculature during the time course of disease in fDTH-EAE, fMOG-EAE and LJP1586-treated fMOG-EAE. The LJP1586 treatment reduced the expression of ICAM-1 only in the acute phase of the disease. Untreated fDTH-EAE rat brains showed weak ICAM-1-positivity in vessels of early pre-active lesions and acute inflammatory lesions. P-selectin-detecting stainings remained negative throughout the studies. Rat brains that had EAE lesions at day 3 or day 14 were stained with ICAM-1 and P-selectin using immunofluorescence. Blue arrows point to ICAM-1 positivity in brain vessels. High power scale bars = 50 μm

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