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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats

Fig. 4

IL-1β enhanced CREB binding to the Nav1.7 promoter. The schematic diagram indicates two potential CREs (CRE1 at − 1702/− 1698 and CRE2 at − 1486/− 1482) in the rat Nav1.7 promoter (− 1788/+ 100, translation start site as + 1). ChIP assay showed that CREB could bind to CRE2, and this binding was enhanced by the treatment with IL-1β for 24 h. The densities of the bands were quantified using the NIH ImageJ 1.38 software and expressed as fold change of the control group after normalization to input band. CRE, cAMP response element

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