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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats

Fig. 6

Upregulation of trigeminal ganglionic IL-1β, COX-2, phospho-CREB, and Nav1.7 accompanied with decrease in the head withdrawal threshold after induction of TMJ inflammation. a Upregulation of IL-1β, COX-2, and Nav1.7 mRNA expressions in TG after induction of TMJ inflammation for 24 h. Independent samples t test, *P < 0.05 versus the control group; n = 3. b Upregulation of IL-1β, COX-2, phospho-CREB, and Nav1.7 protein expressions in TG after induction of TMJ inflammation for 24 h. Quantification of protein expressions were presented as fold change of the control group (lower panel). Independent samples t test, *P < 0.05 versus the control group; n = 3. c Decrease in the head withdrawal threshold after induction of TMJ inflammation for 24 h. Independent samples t test, *P < 0.05 versus the control group; n = 5

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Journal of Neuroinflammation

ISSN: 1742-2094