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Table 2 Cytokine levels in patients with delirium and patients without delirium

From: Reduced ex vivo release of pro-inflammatory cytokines and elevated plasma interleukin-6 are inflammatory signatures of post-stroke delirium

 

Patients with delirium (N = 31)

Patients without delirium (N = 113)

P value

Ex vivo stimulation

 TNFα, pg/103 monocytes

1.76 (1.47–2.32)

3.17 (2.31–4.42)

< 0.01

 IP-10, pg/103 monocytes

0.17 (0.10–0.46)

0.56 (0.32–0.92)

< 0.01

 IL-1β, pg/103 monocytes

1.12 (0.62–1.78)

1.85 (1.26–2.61)

< 0.01

 IL-6, pg/103 monocytes

10.37 (8.55–14.52)

14.21 (9.81–18.16)

0.02

 IL-12, pg/106 monocytes

0 (0–0)

1.46 (0–8.57)

< 0.01

 IL-10, pg/106 monocytes

66.58 (39.57–86.54)

59.70 (36.85–99.02)

0.82

 IL-8, pg/103 monocytes

2.03 (1.51–2.93)

1.64 (1.08–2.56)

0.13

 TNFα, pg/mL

2066 (1578–2550)

2404 (1555–3869)

0.03

 IP-10, pg/mL

166.97 (108.45–366.40)

436.10 (201.28–797.10)

< 0.01

 IL-1β, pg/mL

1153 (680–1690)

1325 (1046–2092)

0.11

 IL-6, pg/mL

10,455 (8885–16,362)

10,407 (7280–13,319)

0.41

 IL-12, pg/mL

0 (0–0)

1.48 (0–6.91)

< 0.01

 IL-10, pg/mL

69.23 (36.67–103.38)

46.62 (31.99–72.11)

0.06

 IL-8, pg/mL

2240 (1469–3209)

1279 (872–2055)

< 0.01

Plasma

 TNFα, pg/ml

0.91 (0.53–1.27)

0.70 (0.36–1.12)

0.09

 IL-6, pg/mL

17.95 (7.09–46.75)

3.94 (2.21–7.29)

< 0.01

  1. Data are shown as medians with interquartiles