Fig. 6From: Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorderIL-1β production by DNA fraction containing abundant mtDNA is dependent on NLRP3 inflammasome and TLR9. IL-1β secretion was suppressed by inhibitors of the NLRP3 inflammasome (MCC950) and TLR9 (ODN2088) in PBMCs. The results are the representative of two independent experiments. The data are expressed as means ± SEM. *p < 0.05Back to article page