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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model

Fig. 2

Activation of glia in the brain from surgical mice. a In the motor cortex, the number of Iba1+ microglia was quantified by using Kruskal-Wallis test with Dunn’s correction, Kruskal-Wallis statistic = 15.11, LAP vs. SEVO, **p = 0.0051; LAP+Ibu vs. LAP, **p = 0.0077. In the sensory cortex, the cell count of Iba1+ microglia was analyzed by using Kruskal-Wallis test with Dunn’s correction, Kruskal-Wallis statistic = 21.76, *p = 0.03, **p = 0.0023, and ***p = 0.0008. In the hippocampus, the number of Iba1+ microglia was quantified by using one-way ANOVA (n = 3–5, F = 5.492; LAP vs. CON, *p = 0.0218; LAP vs. SEVO, **p = 0.0041; LAP+Ibu vs. LAP, *p = 0.0182). Dots in the graphs represent the mean value of the four brain sections per mouse. b The percentage of cell body to the total cell size of Iba1+ microglia was quantified by using one-way ANOVA (n = 3–5). In the motor cortex, F = 7.146; LAP vs. SEVO, *p = 0.0134; LAP+Ibu vs. LAP, *p = 0.0125. In the sensory cortex, F = 10.99; LAP vs. CON, *p = 0.0226; LAP vs. SEVO, *p = 0.0017; LAP+Ibu vs. LAP, *p = 0.0107. In the hippocampus, F = 16.99; LAP vs. CON, *p = 0.0193; LAP vs. SEVO, **p = 0.0002; LAP+Ibu vs. LAP, **p = 0.0029. Dots in the graphs represent the mean value of the four brain sections per mouse. c Representative confocal microphotographs presented the activation of Iba1+ microglia in the hippocampus. d The activation of GFAP+ astrocyte was quantified using one-way ANOVA. In the motor cortex (left), F = 8.969, *p = 0.0452, and **p = 0.0018. In the sensory cortex (right), F = 12.52, *p = 0.0165, **p = 0.0045, and ***p = 0.0007

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