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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation

Fig. 3

TNF blockade promotes OPC differentiation during progressive EAE in GFAPγR1Δ mice. Representative confocal Z-stack images showing CC1 (green), OLIG2 (red), and DAPI (blue) staining within spinal cord demyelinating lesions (dotted line) during a acute (d19) and b chronic (d30) EAE in WT and GFAPγR1Δ mice, treated with isotype control or anti-TNF mAb. White arrows indicate differentiated myelinating CC1+Olig2+ cells. Scale bar, 50 μm. c Quantification of differentiated OLG (CC1+Olig2+) per square millimeter lesion area. d Quantification of OPCs (CC1−Olig2+) per square millimeter lesion area. Data represent the mean values ±SEM from five to seven separate fields per mouse with two to three mice per group of two independent experiments. P values were determined by Wilcoxon rank sum-test. GFAPγR1Δ in all panels represents GFAPγR1Δ mice treated with isotype control mAb

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Journal of Neuroinflammation

ISSN: 1742-2094