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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation

Fig. 4

Reduced TNFR2 mRNA expression in OLG during progressive EAE in GFAPγR1Δ mice. a TNFR1 and TNFR2 mRNA levels determined by RT-PCR of total spinal cord RNA from WT and GFAPγR1Δ mice undergoing EAE at d19 and d30 p.i. Data represent the mean ± SEM of individual mice from two separate experiments, each composed of three to four mice per group. b TNFR1 and TNFR2 mRNA expression in FACS-purified O4+ OLG at d30 p.i assessed by RT-PCR. Data represent mean ± SEM from three individual experiments, each comprising six pooled brains. P values determined by one-way ANOVA. GFAPγR1Δ in all panels represents GFAPγR1Δ mice treated with isotype control mAb

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