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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation

Fig. 8

Model of astrocyte-dependent regulation of remyelination during progressive EAE. IFNγ signaling to astrocytes temporally coordinates the progression of inflammation and primes tissue for repair by limiting OLG apoptosis and promoting OPC differentiation. The absence of IFNγ-mediated anti-inflammatory responses in astrocytes increases astrogliosis and sustains TNF production by infiltrating monocytes, leading to elevated ET-1 expression in both astrocytes and myeloid cells. TNF/TNFR1-mediated interactions promote OLG death while ET-1/EdnRB signaling arrests OPC differentiation. TNF blockade reduces ET-1 and limits progressive demyelinating pathology

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Journal of Neuroinflammation

ISSN: 1742-2094