Fig. 3
From: Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
Pharmacodynamic and anti-inflammatory activity of CPD-4645 in LPS-challenged mouse brain. Inhibition of MAGL by CPD-4645 resulted in significant elevation of brain 2-AG (a) and concomitant reduction in brain AA (b). Levels of the proinflammatory cytokines, IL1β (c) and IL6 (d), were significantly modulated in brain tissue following LPS challenge and CPD-4645 treatment. Bar graphs were plotted with mean ± SEM and data analyzed using one-way analysis of variance (ANOVA) with Bonferroni post-hoc comparisons. n = 10 mice per group. Significance is shown as *p < 0.05; **p < 0.01; ****p < 0.0001