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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Unique and shared inflammatory profiles of human brain endothelia and pericytes

Fig. 3

Inflammatory responses through the NF-κB, STAT1, and SMAD2/3 pathways are conserved between endothelia and pericytes. Endothelia and pericytes were cultured, before treatment with inflammatory mediators (10 ng/mL, 1 h) and transcription factor activation analysis by immunocytochemistry. a Quantification and b representative images of NF-κB translocation in endothelial (red) and pericyte (blue) cultures in response to inflammatory mediators assessed. c Quantification and d representative images of STAT1 activation in endothelial and pericyte cultures in response to inflammatory mediators assessed. e Quantification and f representative images of SMAD2/3 activation in endothelial and pericyte cultures in response to inflammatory mediators assessed. Scale bar = 200 μm. (n = 3, mean ± SEM)

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