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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Anti-high mobility group box 1 antibody suppresses local inflammatory reaction and facilitates olfactory nerve recovery following injury

Fig. 1

An experimental mouse model of severe olfactory bulb deafferentation injury. A horizontal section through the nasal cavities and olfactory bulbs illustrating differences observed between the lesioned (left) and control (right) sides at 5 days after a nerve transection (NTx) injury. The area of injury-associated tissue (enclosed by a black line, *) was measured and quantified within an area surrounded by the cribriform plate (an anterior margin), anterior edge of the olfactory bulb (a posterior margin), a line connecting posterior end of the nasal septal mucosa and the anteriomedial corner of the olfactory bulb (medial margin, green dotted line) and a line connecting posteriolateral end of the most lateral sinus and the anteriolateral corner of the olfactory bulb (lateral margin, yellow dotted line), using ImageJ software (ver.1.50i, NIH, USA). The olfactory nerves and their projections to the glomeruli are labeled using an X-gal staining method (blue color). GL glomerular layer, OB olfactory bulb, ON olfactory nerve, ET II endoturbinate II. Calibration bar = 500 μm

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