TY - JOUR AU - Almkvist, O. AU - Jelic, V. AU - Amberla, K. AU - Hellstrom-Lindahl, E. AU - Meurling, L. AU - Nordberg, A. PY - 2001 DA - 2001// TI - Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients JO - Dement Geriatr Cogn Disord VL - 12 UR - https://doi.org/10.1159/000051232 DO - 10.1159/000051232 ID - Almkvist2001 ER - TY - STD TI - Birks J. Cholinesterase inhibitors for Alzheimer’s disease. Cochrane Database Syst Rev. 2006;25(1):CD005593. ID - ref2 ER - TY - JOUR AU - Winstein, C. J. AU - Bentzen, K. R. AU - Boyd, L. AU - Schneider, L. S. PY - 2007 DA - 2007// TI - Does the cholinesterase inhibitor, donepezil, benefit both declarative and non-declarative processes in mild to moderate Alzheimer’s disease? JO - Curr Alzheimer Res VL - 4 UR - https://doi.org/10.2174/156720507781077296 DO - 10.2174/156720507781077296 ID - Winstein2007 ER - TY - JOUR AU - Onor, M. L. AU - Trevisiol, M. AU - Aguglia, E. PY - 2007 DA - 2007// TI - Rivastigmine in the treatment of Alzheimer’s disease: an update JO - Clin Interv Aging VL - 2 UR - https://doi.org/10.2147/ciia.2007.2.1.17 DO - 10.2147/ciia.2007.2.1.17 ID - Onor2007 ER - TY - JOUR AU - Ott, B. R. AU - Blake, L. M. AU - Kagan, E. AU - Resnick, M. PY - 2007 DA - 2007// TI - Open label, multicenter, 28-week extension study of the safety and tolerability of memantine in patients with mild to moderate Alzheimer’s disease JO - J Neurol VL - 254 UR - https://doi.org/10.1007/s00415-006-0374-x DO - 10.1007/s00415-006-0374-x ID - Ott2007 ER - TY - JOUR AU - Lemere, C. A. PY - 2013 DA - 2013// TI - Immunotherapy for Alzheimer’s disease: hoops and hurdles JO - Mol Neurodegener VL - 8 UR - https://doi.org/10.1186/1750-1326-8-36 DO - 10.1186/1750-1326-8-36 ID - Lemere2013 ER - TY - JOUR AU - Panza, F. AU - Logroscino, G. AU - Imbimbo, B. P. AU - Solfrizzi, V. PY - 2014 DA - 2014// TI - Is there still any hope for amyloid-based immunotherapy for Alzheimer’s disease? JO - Curr Opin Psychiatry VL - 27 UR - https://doi.org/10.1097/YCO.0000000000000041 DO - 10.1097/YCO.0000000000000041 ID - Panza2014 ER - TY - JOUR AU - Daulatzai, M. A. PY - 2013 DA - 2013// TI - Neurotoxic saboteurs: straws that break the hippo’s (hippocampus) back drive cognitive impairment and Alzheimer’s disease JO - Neurotox Res VL - 24 UR - https://doi.org/10.1007/s12640-013-9407-2 DO - 10.1007/s12640-013-9407-2 ID - Daulatzai2013 ER - TY - JOUR AU - Crary, J. F. PY - 2016 DA - 2016// TI - Primary age-related tauopathy and the amyloid cascade hypothesis: the exception that proves the rule? JO - J Neurol Neuromedicine VL - 1 UR - https://doi.org/10.29245/2572.942X/2016/6.1059 DO - 10.29245/2572.942X/2016/6.1059 ID - Crary2016 ER - TY - JOUR AU - McGeer, P. L. AU - McGeer, E. G. PY - 2015 DA - 2015// TI - Targeting microglia for the treatment of Alzheimer’s disease JO - Expert Opin Ther Targets VL - 19 UR - https://doi.org/10.1517/14728222.2014.988707 DO - 10.1517/14728222.2014.988707 ID - McGeer2015 ER - TY - JOUR AU - Heneka, M. T. AU - Carson, M. J. AU - El Khoury, J. AU - Landreth, G. E. AU - Brosseron, F. AU - Feinstein, D. L. AU - Jacobs, A. H. AU - Wyss-Coray, T. AU - Vitorica, J. AU - Ransohoff, R. M. PY - 2015 DA - 2015// TI - Neuroinflammation in Alzheimer’s disease JO - Lancet Neurol VL - 14 UR - https://doi.org/10.1016/S1474-4422(15)70016-5 DO - 10.1016/S1474-4422(15)70016-5 ID - Heneka2015 ER - TY - JOUR AU - Andreasson, K. I. AU - Bachstetter, A. D. AU - Colonna, M. AU - Ginhoux, F. AU - Holmes, C. AU - Lamb, B. AU - Landreth, G. AU - Lee, D. C. AU - Low, D. AU - Lynch, M. A. PY - 2016 DA - 2016// TI - Targeting innate immunity for neurodegenerative disorders of the central nervous system JO - J Neurochem VL - 138 UR - https://doi.org/10.1111/jnc.13667 DO - 10.1111/jnc.13667 ID - Andreasson2016 ER - TY - JOUR AU - Seger, R. AU - Krebs, E. G. PY - 1995 DA - 1995// TI - The MAPK signaling cascade JO - FASEB J VL - 9 UR - https://doi.org/10.1096/fasebj.9.9.7601337 DO - 10.1096/fasebj.9.9.7601337 ID - Seger1995 ER - TY - JOUR AU - Wang, L. H. AU - Besirli, C. G. AU - Johnson, E. M. PY - 2004 DA - 2004// TI - Mixed-lineage kinases: a target for the prevention of neurodegeneration JO - Annu Rev Pharmacol Toxicol VL - 44 UR - https://doi.org/10.1146/annurev.pharmtox.44.101802.121840 DO - 10.1146/annurev.pharmtox.44.101802.121840 ID - Wang2004 ER - TY - JOUR AU - Zhou, F. AU - Xu, Y. AU - Hou, X. Y. PY - 2014 DA - 2014// TI - MLK3-MKK3/6-P38MAPK cascades following N-methyl-D-aspartate receptor activation contributes to amyloid-beta peptide-induced apoptosis in SH-SY5Y cells JO - J Neurosci Res VL - 92 UR - https://doi.org/10.1002/jnr.23354 DO - 10.1002/jnr.23354 ID - Zhou2014 ER - TY - JOUR AU - Marker, D. F. AU - Tremblay, M. E. AU - Puccini, J. M. AU - Barbieri, J. AU - Gantz Marker, M. A. AU - Loweth, C. J. AU - Muly, E. C. AU - Lu, S. M. AU - Goodfellow, V. S. AU - Dewhurst, S. AU - Gelbard, H. A. PY - 2013 DA - 2013// TI - The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders JO - J Neurosci VL - 33 UR - https://doi.org/10.1523/JNEUROSCI.0598-13.2013 DO - 10.1523/JNEUROSCI.0598-13.2013 ID - Marker2013 ER - TY - JOUR AU - Goodfellow, V. S. AU - Loweth, C. J. AU - Ravula, S. B. AU - Wiemann, T. AU - Nguyen, T. AU - Xu, Y. AU - Todd, D. E. AU - Sheppard, D. AU - Pollack, S. AU - Polesskaya, O. PY - 2013 DA - 2013// TI - Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 JO - J Med Chem VL - 56 UR - https://doi.org/10.1021/jm401094t DO - 10.1021/jm401094t ID - Goodfellow2013 ER - TY - JOUR AU - Dong, W. AU - Embury, C. M. AU - Lu, Y. AU - Whitmire, S. M. AU - Dyavarshetty, B. AU - Gelbard, H. A. AU - Gendelman, H. E. AU - Kiyota, T. PY - 2016 DA - 2016// TI - The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-beta degradation JO - J Neuroinflammation VL - 13 UR - https://doi.org/10.1186/s12974-016-0646-z DO - 10.1186/s12974-016-0646-z ID - Dong2016 ER - TY - JOUR AU - Hsiao, K. AU - Chapman, P. AU - Nilsen, S. AU - Eckman, C. AU - Harigaya, Y. AU - Younkin, S. AU - Yang, F. AU - Cole, G. PY - 1996 DA - 1996// TI - Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice JO - Science VL - 274 UR - https://doi.org/10.1126/science.274.5284.99 DO - 10.1126/science.274.5284.99 ID - Hsiao1996 ER - TY - JOUR AU - Duff, K. AU - Eckman, C. AU - Zehr, C. AU - Yu, X. AU - Prada, C. M. AU - Perez-tur, J. AU - Hutton, M. AU - Buee, L. AU - Harigaya, Y. AU - Yager, D. PY - 1996 DA - 1996// TI - Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1 JO - Nature VL - 383 UR - https://doi.org/10.1038/383710a0 DO - 10.1038/383710a0 ID - Duff1996 ER - TY - JOUR AU - Kiyota, T. AU - Yamamoto, M. AU - Schroder, B. AU - Jacobsen, M. T. AU - Swan, R. J. AU - Lambert, M. P. AU - Klein, W. L. AU - Gendelman, H. E. AU - Ransohoff, R. M. AU - Ikezu, T. PY - 2009 DA - 2009// TI - AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice JO - Mol Ther VL - 17 UR - https://doi.org/10.1038/mt.2009.44 DO - 10.1038/mt.2009.44 ID - Kiyota2009 ER - TY - JOUR AU - Kiyota, T. AU - Ingraham, K. L. AU - Jacobsen, M. T. AU - Xiong, H. AU - Ikezu, T. PY - 2011 DA - 2011// TI - FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer’s disease and has therapeutic implications for neurocognitive disorders JO - Proc Natl Acad Sci U S A VL - 108 UR - https://doi.org/10.1073/pnas.1102349108 DO - 10.1073/pnas.1102349108 ID - Kiyota2011 ER - TY - JOUR AU - Kiyota, T. AU - Gendelman, H. E. AU - Weir, R. A. AU - Higgins, E. E. AU - Zhang, G. AU - Jain, M. PY - 2013 DA - 2013// TI - CCL2 affects beta-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer’s disease JO - Neurobiol Aging VL - 34 UR - https://doi.org/10.1016/j.neurobiolaging.2012.08.009 DO - 10.1016/j.neurobiolaging.2012.08.009 ID - Kiyota2013 ER - TY - STD TI - Zhang G, Guo D, Dash PK, Arainga M, Wiederin JL, Haverland NA, Knibbe-Hollinger J, Martinez-Skinner A, Ciborowski P, Goodfellow VS, et al. The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy. Nanomedicine. 2016;12(1):109–22. https://doi.org/10.1016/j.nano.2015.09.009. Epub 2015 Oct 22 ID - ref24 ER - TY - STD TI - Tomita K, Kohli R, MacLaurin BL, Hirsova P, Guo Q, Sanchez LHG, Gelbard HA, Blaxall BC, Ibrahim SH. Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis. JCI Insight. 2017;2(15). https://doi.org/10.1172/jci.insight.94488. [Epub ahead of print] ID - ref25 ER - TY - JOUR AU - Lesne, S. AU - Koh, M. T. AU - Kotilinek, L. AU - Kayed, R. AU - Glabe, C. G. AU - Yang, A. AU - Gallagher, M. AU - Ashe, K. H. PY - 2006 DA - 2006// TI - A specific amyloid-beta protein assembly in the brain impairs memory JO - Nature VL - 440 UR - https://doi.org/10.1038/nature04533 DO - 10.1038/nature04533 ID - Lesne2006 ER - TY - JOUR AU - Kiyota, T. AU - Zhang, G. AU - Morrison, C. M. AU - Bosch, M. E. AU - Weir, R. A. AU - Lu, Y. AU - Dong, W. AU - Gendelman, H. E. PY - 2015 DA - 2015// TI - AAV2/1 CD74 gene transfer reduces beta-amyloidosis and Improves learning and memory in a mouse model of Alzheimer’s disease JO - Mol Ther VL - 23 UR - https://doi.org/10.1038/mt.2015.142 DO - 10.1038/mt.2015.142 ID - Kiyota2015 ER - TY - JOUR AU - Kiyota, T. AU - Morrison, C. M. AU - Tu, G. AU - Dyavarshetty, B. AU - Weir, R. A. AU - Zhang, G. AU - Xiong, H. AU - Gendelman, H. E. PY - 2015 DA - 2015// TI - Presenilin-1 familial Alzheimer’s disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice JO - Brain Behav Immun VL - 49 UR - https://doi.org/10.1016/j.bbi.2015.06.014 DO - 10.1016/j.bbi.2015.06.014 ID - Kiyota2015 ER - TY - JOUR AU - Polesskaya, O. AU - Wong, C. AU - Lebron, L. AU - Chamberlain, J. M. AU - Gelbard, H. A. AU - Goodfellow, V. AU - Kim, M. AU - Daiss, J. L. AU - Dewhurst, S. PY - 2014 DA - 2014// TI - MLK3 regulates fMLP-stimulated neutrophil motility JO - Mol Immunol VL - 58 UR - https://doi.org/10.1016/j.molimm.2013.11.016 DO - 10.1016/j.molimm.2013.11.016 ID - Polesskaya2014 ER - TY - JOUR AU - Do, T. M. AU - Dodacki, A. AU - Alata, W. AU - Calon, F. AU - Nicolic, S. AU - Scherrmann, J. M. AU - Farinotti, R. AU - Bourasset, F. PY - 2016 DA - 2016// TI - Age-dependent regulation of the blood-brain barrier influx/efflux equilibrium of amyloid-beta peptide in a mouse model of Alzheimer’s disease (3xTg-AD) JO - J Alzheimers Dis VL - 49 UR - https://doi.org/10.3233/JAD-150350 DO - 10.3233/JAD-150350 ID - Do2016 ER - TY - JOUR AU - Herring, A. AU - Munster, Y. AU - Akkaya, T. AU - Moghaddam, S. AU - Deinsberger, K. AU - Meyer, J. AU - Zahel, J. AU - Sanchez-Mendoza, E. AU - Wang, Y. AU - Hermann, D. M. PY - 2016 DA - 2016// TI - Kallikrein-8 inhibition attenuates Alzheimer’s disease pathology in mice JO - Alzheimers Dement VL - 12 UR - https://doi.org/10.1016/j.jalz.2016.05.006 DO - 10.1016/j.jalz.2016.05.006 ID - Herring2016 ER - TY - JOUR AU - Tang, Y. AU - Le, W. PY - 2016 DA - 2016// TI - Differential roles of M1 and M2 microglia in neurodegenerative diseases JO - Mol Neurobiol VL - 53 UR - https://doi.org/10.1007/s12035-014-9070-5 DO - 10.1007/s12035-014-9070-5 ID - Tang2016 ER - TY - JOUR AU - Song, G. J. AU - Suk, K. PY - 2017 DA - 2017// TI - Pharmacological modulation of functional phenotypes of microglia in neurodegenerative diseases JO - Front Aging Neurosci VL - 9 UR - https://doi.org/10.3389/fnagi.2017.00139 DO - 10.3389/fnagi.2017.00139 ID - Song2017 ER - TY - JOUR AU - Dumitriu, D. AU - Hao, J. AU - Hara, Y. AU - Kaufmann, J. AU - Janssen, W. G. AU - Lou, W. AU - Rapp, P. R. AU - Morrison, J. H. PY - 2010 DA - 2010// TI - Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment JO - J Neurosci VL - 30 UR - https://doi.org/10.1523/JNEUROSCI.6410-09.2010 DO - 10.1523/JNEUROSCI.6410-09.2010 ID - Dumitriu2010 ER - TY - JOUR AU - Glantz, L. A. AU - Gilmore, J. H. AU - Hamer, R. M. AU - Lieberman, J. A. AU - Jarskog, L. F. PY - 2007 DA - 2007// TI - Synaptophysin and postsynaptic density protein 95 in the human prefrontal cortex from mid-gestation into early adulthood JO - Neuroscience VL - 149 UR - https://doi.org/10.1016/j.neuroscience.2007.06.036 DO - 10.1016/j.neuroscience.2007.06.036 ID - Glantz2007 ER - TY - JOUR AU - Head, E. AU - Corrada, M. M. AU - Kahle-Wrobleski, K. AU - Kim, R. C. AU - Sarsoza, F. AU - Goodus, M. AU - Kawas, C. H. PY - 2009 DA - 2009// TI - Synaptic proteins, neuropathology and cognitive status in the oldest-old JO - Neurobiol Aging VL - 30 UR - https://doi.org/10.1016/j.neurobiolaging.2007.10.001 DO - 10.1016/j.neurobiolaging.2007.10.001 ID - Head2009 ER - TY - JOUR AU - VanGuilder, H. D. AU - Yan, H. AU - Farley, J. A. AU - Sonntag, W. E. AU - Freeman, W. M. PY - 2010 DA - 2010// TI - Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome JO - J Neurochem VL - 113 ID - VanGuilder2010 ER - TY - JOUR AU - Azizi, G. AU - Khannazer, N. AU - Mirshafiey, A. PY - 2014 DA - 2014// TI - The potential role of chemokines in Alzheimer’s disease pathogenesis JO - Am J Alzheimers Dis Other Demen VL - 29 UR - https://doi.org/10.1177/1533317513518651 DO - 10.1177/1533317513518651 ID - Azizi2014 ER - TY - JOUR AU - Calsolaro, V. AU - Edison, P. PY - 2016 DA - 2016// TI - Neuroinflammation in Alzheimer’s disease: current evidence and future directions JO - Alzheimers Dement VL - 12 UR - https://doi.org/10.1016/j.jalz.2016.02.010 DO - 10.1016/j.jalz.2016.02.010 ID - Calsolaro2016 ER - TY - JOUR AU - Bozyczko-Coyne, D. AU - O’Kane, T. M. AU - Wu, Z. L. AU - Dobrzanski, P. AU - Murthy, S. AU - Vaught, J. L. AU - Scott, R. W. PY - 2001 DA - 2001// TI - CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis JO - J Neurochem VL - 77 UR - https://doi.org/10.1046/j.1471-4159.2001.00294.x DO - 10.1046/j.1471-4159.2001.00294.x ID - Bozyczko-Coyne2001 ER - TY - JOUR AU - Troy, C. M. AU - Rabacchi, S. A. AU - Xu, Z. AU - Maroney, A. C. AU - Connors, T. J. AU - Shelanski, M. L. AU - Greene, L. A. PY - 2001 DA - 2001// TI - Beta-amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation JO - J Neurochem VL - 77 UR - https://doi.org/10.1046/j.1471-4159.2001.t01-1-00218.x DO - 10.1046/j.1471-4159.2001.t01-1-00218.x ID - Troy2001 ER - TY - JOUR AU - Fiala, M. AU - Cribbs, D. H. AU - Rosenthal, M. AU - Bernard, G. PY - 2007 DA - 2007// TI - Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer’s disease JO - J Alzheimers Dis VL - 11 UR - https://doi.org/10.3233/JAD-2007-11406 DO - 10.3233/JAD-2007-11406 ID - Fiala2007 ER - TY - JOUR AU - Heneka, M. T. AU - Rodriguez, J. J. AU - Verkhratsky, A. PY - 2010 DA - 2010// TI - Neuroglia in neurodegeneration JO - Brain Res Rev VL - 63 UR - https://doi.org/10.1016/j.brainresrev.2009.11.004 DO - 10.1016/j.brainresrev.2009.11.004 ID - Heneka2010 ER - TY - JOUR AU - Hanisch, U. K. AU - Kettenmann, H. PY - 2007 DA - 2007// TI - Microglia: active sensor and versatile effector cells in the normal and pathologic brain JO - Nat Neurosci VL - 10 UR - https://doi.org/10.1038/nn1997 DO - 10.1038/nn1997 ID - Hanisch2007 ER - TY - JOUR AU - Lee, C. Y. AU - Landreth, G. E. PY - 2010 DA - 2010// TI - The role of microglia in amyloid clearance from the AD brain JO - J Neural Transm (Vienna) VL - 117 UR - https://doi.org/10.1007/s00702-010-0433-4 DO - 10.1007/s00702-010-0433-4 ID - Lee2010 ER - TY - JOUR AU - Perry, V. H. AU - Nicoll, J. A. AU - Holmes, C. PY - 2010 DA - 2010// TI - Microglia in neurodegenerative disease JO - Nat Rev Neurol VL - 6 UR - https://doi.org/10.1038/nrneurol.2010.17 DO - 10.1038/nrneurol.2010.17 ID - Perry2010 ER - TY - STD TI - Tang Y, Le W. Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol. 2015; ID - ref47 ER - TY - JOUR AU - Ajmone-Cat, M. A. AU - Mancini, M. AU - De Simone, R. AU - Cilli, P. AU - Minghetti, L. PY - 2013 DA - 2013// TI - Microglial polarization and plasticity: evidence from organotypic hippocampal slice cultures JO - Glia VL - 61 UR - https://doi.org/10.1002/glia.22550 DO - 10.1002/glia.22550 ID - Ajmone-Cat2013 ER - TY - JOUR AU - Gordon, S. PY - 2003 DA - 2003// TI - Alternative activation of macrophages JO - Nat Rev Immunol VL - 3 UR - https://doi.org/10.1038/nri978 DO - 10.1038/nri978 ID - Gordon2003 ER - TY - JOUR AU - Ferrante, C. J. AU - Leibovich, S. J. PY - 2012 DA - 2012// TI - Regulation of macrophage polarization and wound healing JO - Adv Wound Care (New Rochelle) VL - 1 UR - https://doi.org/10.1089/wound.2011.0307 DO - 10.1089/wound.2011.0307 ID - Ferrante2012 ER - TY - JOUR AU - Varnum, M. M. AU - Ikezu, T. PY - 2012 DA - 2012// TI - The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer’s disease brain JO - Arch Immunol Ther Exp VL - 60 UR - https://doi.org/10.1007/s00005-012-0181-2 DO - 10.1007/s00005-012-0181-2 ID - Varnum2012 ER - TY - JOUR AU - Szczepanik, A. M. AU - Funes, S. AU - Petko, W. AU - Ringheim, G. E. PY - 2001 DA - 2001// TI - IL-4, IL-10 and IL-13 modulate a beta(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line JO - J Neuroimmunol VL - 113 UR - https://doi.org/10.1016/S0165-5728(00)00404-5 DO - 10.1016/S0165-5728(00)00404-5 ID - Szczepanik2001 ER - TY - JOUR AU - Parvathy, S. AU - Rajadas, J. AU - Ryan, H. AU - Vaziri, S. AU - Anderson, L. AU - Murphy, G. M. PY - 2009 DA - 2009// TI - Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells JO - Neurobiol Aging VL - 30 UR - https://doi.org/10.1016/j.neurobiolaging.2008.01.011 DO - 10.1016/j.neurobiolaging.2008.01.011 ID - Parvathy2009 ER - TY - JOUR AU - Neher, J. J. AU - Neniskyte, U. AU - Zhao, J. W. AU - Bal-Price, A. AU - Tolkovsky, A. M. AU - Brown, G. C. PY - 2011 DA - 2011// TI - Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death JO - J Immunol VL - 186 UR - https://doi.org/10.4049/jimmunol.1003600 DO - 10.4049/jimmunol.1003600 ID - Neher2011 ER - TY - JOUR AU - Murgas, P. AU - Godoy, B. AU - von Bernhardi, R. PY - 2012 DA - 2012// TI - Abeta potentiates inflammatory activation of glial cells induced by scavenger receptor ligands and inflammatory mediators in culture JO - Neurotox Res VL - 22 UR - https://doi.org/10.1007/s12640-011-9306-3 DO - 10.1007/s12640-011-9306-3 ID - Murgas2012 ER - TY - JOUR AU - Taneo, J. AU - Adachi, T. AU - Yoshida, A. AU - Takayasu, K. AU - Takahara, K. AU - Inaba, K. PY - 2015 DA - 2015// TI - Amyloid beta oligomers induce interleukin-1beta production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner JO - Biochem Biophys Res Commun VL - 458 UR - https://doi.org/10.1016/j.bbrc.2015.02.006 DO - 10.1016/j.bbrc.2015.02.006 ID - Taneo2015 ER - TY - JOUR AU - Qin, L. AU - Liu, Y. AU - Cooper, C. AU - Liu, B. AU - Wilson, B. AU - Hong, J. S. PY - 2002 DA - 2002// TI - Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species JO - J Neurochem VL - 83 UR - https://doi.org/10.1046/j.1471-4159.2002.01210.x DO - 10.1046/j.1471-4159.2002.01210.x ID - Qin2002 ER - TY - JOUR AU - Szaingurten-Solodkin, I. AU - Hadad, N. AU - Levy, R. PY - 2009 DA - 2009// TI - Regulatory role of cytosolic phospholipase A2alpha in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Abeta1-42 in microglia JO - Glia VL - 57 UR - https://doi.org/10.1002/glia.20886 DO - 10.1002/glia.20886 ID - Szaingurten-Solodkin2009 ER - TY - JOUR AU - Cherry, J. D. AU - Olschowka, J. A. AU - O’Banion, M. K. PY - 2014 DA - 2014// TI - Neuroinflammation and M2 microglia: the good, the bad, and the inflamed JO - J Neuroinflammation VL - 11 UR - https://doi.org/10.1186/1742-2094-11-98 DO - 10.1186/1742-2094-11-98 ID - Cherry2014 ER - TY - JOUR AU - Cherry, J. D. AU - Olschowka, J. A. AU - O’Banion, M. K. PY - 2015 DA - 2015// TI - Arginase 1+ microglia reduce Abeta plaque deposition during IL-1beta-dependent neuroinflammation JO - J Neuroinflammation VL - 12 UR - https://doi.org/10.1186/s12974-015-0411-8 DO - 10.1186/s12974-015-0411-8 ID - Cherry2015 ER - TY - JOUR AU - Koenigsknecht-Talboo, J. AU - Landreth, G. E. PY - 2005 DA - 2005// TI - Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines JO - J Neurosci VL - 25 UR - https://doi.org/10.1523/JNEUROSCI.1808-05.2005 DO - 10.1523/JNEUROSCI.1808-05.2005 ID - Koenigsknecht-Talboo2005 ER - TY - JOUR AU - Goerdt, S. AU - Orfanos, C. E. PY - 1999 DA - 1999// TI - Other functions, other genes: alternative activation of antigen-presenting cells JO - Immunity VL - 10 UR - https://doi.org/10.1016/S1074-7613(00)80014-X DO - 10.1016/S1074-7613(00)80014-X ID - Goerdt1999 ER - TY - JOUR AU - Zelcer, N. AU - Khanlou, N. AU - Clare, R. AU - Jiang, Q. AU - Reed-Geaghan, E. G. AU - Landreth, G. E. AU - Vinters, H. V. AU - Tontonoz, P. PY - 2007 DA - 2007// TI - Attenuation of neuroinflammation and Alzheimer’s disease pathology by liver x receptors JO - Proc Natl Acad Sci U S A VL - 104 UR - https://doi.org/10.1073/pnas.0701096104 DO - 10.1073/pnas.0701096104 ID - Zelcer2007 ER - TY - JOUR AU - Takata, K. AU - Kitamura, Y. AU - Saeki, M. AU - Terada, M. AU - Kagitani, S. AU - Kitamura, R. AU - Fujikawa, Y. AU - Maelicke, A. AU - Tomimoto, H. AU - Taniguchi, T. AU - Shimohama, S. PY - 2010 DA - 2010// TI - Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.142356 DO - 10.1074/jbc.M110.142356 ID - Takata2010 ER - TY - JOUR AU - Yatsushige, H. AU - Ostrowski, R. P. AU - Tsubokawa, T. AU - Colohan, A. AU - Zhang, J. H. PY - 2007 DA - 2007// TI - Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage JO - J Neurosci Res VL - 85 UR - https://doi.org/10.1002/jnr.21281 DO - 10.1002/jnr.21281 ID - Yatsushige2007 ER - TY - JOUR AU - Li, J. AU - Li, Y. AU - Ogle, M. AU - Zhou, X. AU - Song, M. AU - Yu, S. P. AU - Wei, L. PY - 2010 DA - 2010// TI - DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway JO - Brain Res VL - 1359 UR - https://doi.org/10.1016/j.brainres.2010.08.061 DO - 10.1016/j.brainres.2010.08.061 ID - Li2010 ER - TY - JOUR AU - Chen, C. Y. AU - Weng, Y. H. AU - Chien, K. Y. AU - Lin, K. J. AU - Yeh, T. H. AU - Cheng, Y. P. AU - Lu, C. S. PY - 2012 DA - 2012// TI - Wang HL: (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD JO - Cell Death Differ VL - 19 UR - https://doi.org/10.1038/cdd.2012.42 DO - 10.1038/cdd.2012.42 ID - Chen2012 ER - TY - JOUR AU - Xu, Z. AU - Maroney, A. C. AU - Dobrzanski, P. AU - Kukekov, N. V. AU - Greene, L. A. PY - 2001 DA - 2001// TI - The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis JO - Mol Cell Biol VL - 21 UR - https://doi.org/10.1128/MCB.21.14.4713-4724.2001 DO - 10.1128/MCB.21.14.4713-4724.2001 ID - Xu2001 ER - TY - JOUR AU - Zhao, J. AU - Pei, D. S. AU - Zhang, Q. G. AU - Zhang, G. Y. PY - 2007 DA - 2007// TI - Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus JO - Cell Signal VL - 19 UR - https://doi.org/10.1016/j.cellsig.2006.10.006 DO - 10.1016/j.cellsig.2006.10.006 ID - Zhao2007 ER - TY - JOUR AU - Du, Y. AU - Li, C. AU - Hu, W. W. AU - Song, Y. J. AU - Zhang, G. Y. PY - 2009 DA - 2009// TI - Neuroprotection of preconditioning against ischemic brain injury in rat hippocampus through inhibition of the assembly of GluR6-PSD95-mixed lineage kinase 3 signaling module via nuclear and non-nuclear pathways JO - Neuroscience VL - 161 UR - https://doi.org/10.1016/j.neuroscience.2009.03.050 DO - 10.1016/j.neuroscience.2009.03.050 ID - Du2009 ER - TY - JOUR AU - Kogel, D. AU - Deller, T. AU - Behl, C. PY - 2012 DA - 2012// TI - Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging JO - Exp Brain Res VL - 217 UR - https://doi.org/10.1007/s00221-011-2932-4 DO - 10.1007/s00221-011-2932-4 ID - Kogel2012 ER - TY - JOUR AU - Yang, H. Q. AU - Ba, M. W. AU - Ren, R. J. AU - Zhang, Y. H. AU - Ma, J. F. AU - Pan, J. AU - Lu, G. Q. AU - Chen, S. D. PY - 2007 DA - 2007// TI - Mitogen activated protein kinase and protein kinase C activation mediate promotion of sAPPalpha secretion by deprenyl JO - Neurochem Int VL - 50 UR - https://doi.org/10.1016/j.neuint.2006.07.016 DO - 10.1016/j.neuint.2006.07.016 ID - Yang2007 ER - TY - JOUR AU - Kogel, D. AU - Schomburg, R. AU - Copanaki, E. AU - Prehn, J. H. PY - 2005 DA - 2005// TI - Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway JO - Cell Death Differ VL - 12 UR - https://doi.org/10.1038/sj.cdd.4401495 DO - 10.1038/sj.cdd.4401495 ID - Kogel2005 ER -