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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease

Fig. 1

URMC-099 inhibits p38/JNK/MAPK signaling cascade in vivo. Immunoblots of p-MKK3 and total MKK3 (a), p-MKK4 and total MKK4 (c), p-p38 and total p38 (e), p-JNK p54 (top), p46 (bottom), and total JNK (g). Densitometric analysis of p-MKK3 (b), p-MKK4 (d), p-p38 (f), p-JNK p54 (h), and p46 (i). Data are presented as mean ± S.E.M. a,b,cp < 0.05, aa,bb,ccp < 0.01, aaa,bbbp < 0.001 a vs non-Tg, b vs APP/PS1 control, c vs APP/PS1/vehicle, one-way ANOVA, and Newman-Keuls post hoc test

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