Fig. 10
From: URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease
Prospective schematic diagram of URMC-099-mediated neuroprotective effects in APP/PS1 mice. Microglia acquires classical or alternative activation in Aβ vicinity. Classical microglial activation induces pro-inflammatory cytokines causing neuroinflammation and ultimately neurodegeneration developing AD-like conditions (left). URMC-099 facilitates alternative microglial activation, a more anti-inflammatory phenotype that phagocytes and degrades Aβ imparting neuroprotection in AD (right)