Fig. 2

URMC-099 reduces Aβ load in the cortex and the hippocampus of APP/PS1 mice. a Representative images of Aβ DAB staining in the APP/PS1 mouse brain, and quantification was performed by measuring percentage-occupied area of the whole cortex (b) and the hippocampus (c), respectively. Scale bar = 500 μm (n = 5 per group, 12 sections per brain). Data are presented as mean ± S.E.M. ^bp < 0.05, ^aap < 0.01, ^a vs APP/PS1 control, ^b vs APP/PS1/vehicle, one-way ANOVA, and Newman-Keuls post hoc test