Skip to main content
Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease

Fig. 5

URMC-099 alters microglial morphology in APP/PS1 mice. a Representative images of Iba1 staining in the cortex and the hippocampus of APP/PS1 mice are shown. Scale bar = 50 μm. b, c Quantification of total Iba1 cell count in the cortex (b) and the hippocampus (c) of the brain. d, e Quantification of the area of Iba1-positive cells including cell processes per area (μm2) in the cortex (d) and the hippocampus (e) (n = 5 per group, 12 sections per brain, three areas/section) are shown. f, g Quantification of Iba1 cell body volume in the cortex (f) and the hippocampus (g) of the brain. h Representative reconstruction of Iba1 cell process in three dimensions. i, j Quantification of Iba1 cell process length in the cortex (i) and the hippocampus (j). Data are presented as mean ± S.E.M. a,b,cp < 0.05, aa,bb,ccp < 0.01, aaap < 0.001, a vs non-Tg, b vs APP/PS1, c vs APP/PS1/vehicle, one-way ANOVA, and Newman-Keuls post hoc test

Back to article page