Fig. 6

Consequences of CB₂ deletion in the context of AD. The genetic inactivation of CB₂ in CB₂^−/−/5xFAD mice led to a significant decrease in plaque density in hippocampus (a), without any changes in soluble amyloid production (b), or microgliosis (c). No changes were observed in the expression of IL1β as a consequence of gene deletion (d) in CB₂^−/−/5xFAD mice as compared to those in CB₂^EGFP/f/f/5xFAD mice. Data are expressed as mean ± SEM. *p < 0.05. Student’s t-test (a, b) and two-way ANOVA followed by Tukey’s post hoc test (c, d). N = 5 for immunofluorescence labeling measurements and N = 6 for experiments on soluble amyloid quantification and IL1β expression