Table 1 Baseline clinical characteristics in patients with and without post-stroke major depression at 6 months

N

835

370

–

Age (years), median (IQR)

64 (56–75)

69 (57–78)

0.001

Male, n (%)

430 (51.5)

210 (56.8)

0.450

BMI (kg/m²), median (IQR)

26.8 (24.2–28.7)

27.2 (24.3–28.8)

0.312

Stroke severity, median NIHSS score (IQR)

6 (3–9)

11 (6–16)

0.005

Lesion volumes (mL), median (IQR)

32 (7–61)

48 (14–75)

0.009

mRS at 3 months, median (IQR)

1 (0–2)

1 (1–2)

0.252

 Hypertension

67.1

70.2

0.683

 Diabetes mellitus

34.1

38.3

0.597

 Coronary heart disease

31.1

34.0

0.706

 Family history for stroke

21.0

25.5

0.503

 Current smoking

22.2

23.4

0.856

 Antiplatelet agents

31.7

34.0

0.765

 Anticoagulants

21.0

23.4

0.718

 Family history of psychiatric disorders (%)

10.2

27.7

0.002

 Widowhood (%)

9.0

25.5

0.003

 Living with offspring (%)

10.2

27.7

0.002

Stroke etiology (%)

0.623

 Atherothrombotic

32.9

29.8

 Cardioembolic

28.7

25.5

 Lacunar

16.8

23.4

 Unknown

21.6

21.3

Lesion location (%)

0.371

 Frontal

26.9

21.3

 Parietal

14.4

19.1

 Basal ganglia

20.4

21.3

 Posterior fossa

17.4

21.3

 Other

21.0

17.0

 Glucose (mmol L⁻¹)

6.18 (5.54–6.75)

6.22 (5.58–6.85)

0.206

 Hs-CRP (mg dL⁻¹)

0.48 (0.24–0.69)

0.75 (0.46–1.23)

0.009

 HCY (mmol L⁻¹)

13.8 (9.6–16.5)

17.2 (12.1–21.6)

0.018

 TC (mmol L⁻¹)

4.86 (4.32–5.36)

4.90 (4.32–5.41)

0.428

 TG (mmol L⁻¹)

1.89 (1.43–2.21)

1.88 (1.40–2.26)

0.501

 HDL-C (mmol L⁻¹)

1.16 (1.03–1.24)

1.18 (1.05–1.29)

0.332

 LDL-C (mmol L⁻¹)

2.48 (2.11–2.76)

2.40 (2.04–2.83)

0.242

 IL-6 (pg mL⁻¹)

101.2 (76.5–138.6)

132.2 (102.3–164.8)

0.003

 HOMA-IR

2.13 (1.52–3.04)

2.20 (1.62–3.11)

0.151

 Irisin (ng mL⁻¹)

120.3 (77.6–164.8)

74.2 (60.4–108.4)

< 0.001