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Table 1 Baseline clinical characteristics in patients with and without post-stroke major depression at 6 months

From: Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population

  No depression Depression P
N 835 370
Age (years), median (IQR) 64 (56–75) 69 (57–78) 0.001
Male, n (%) 430 (51.5) 210 (56.8) 0.450
BMI (kg/m2), median (IQR) 26.8 (24.2–28.7) 27.2 (24.3–28.8) 0.312
Stroke severity, median NIHSS score (IQR) 6 (3–9) 11 (6–16) 0.005
Lesion volumes (mL), median (IQR) 32 (7–61) 48 (14–75) 0.009
mRS at 3 months, median (IQR) 1 (0–2) 1 (1–2) 0.252
Vascular risk factors (%)
 Hypertension 67.1 70.2 0.683
 Diabetes mellitus 34.1 38.3 0.597
 Coronary heart disease 31.1 34.0 0.706
 Family history for stroke 21.0 25.5 0.503
 Current smoking 22.2 23.4 0.856
Pre-stroke treatment (%)
 Antiplatelet agents 31.7 34.0 0.765
 Anticoagulants 21.0 23.4 0.718
Endovascular/surgical revascularization (%)
 Family history of psychiatric disorders (%) 10.2 27.7 0.002
 Widowhood (%) 9.0 25.5 0.003
 Living with offspring (%) 10.2 27.7 0.002
Stroke etiology (%)    0.623
 Atherothrombotic 32.9 29.8  
 Cardioembolic 28.7 25.5
 Lacunar 16.8 23.4
 Unknown 21.6 21.3
Lesion location (%)    0.371
 Frontal 26.9 21.3  
 Parietal 14.4 19.1
 Basal ganglia 20.4 21.3
 Posterior fossa 17.4 21.3
 Other 21.0 17.0
Laboratory findings, median (IQR)
 Glucose (mmol L−1) 6.18 (5.54–6.75) 6.22 (5.58–6.85) 0.206
 Hs-CRP (mg dL−1) 0.48 (0.24–0.69) 0.75 (0.46–1.23) 0.009
 HCY (mmol L−1) 13.8 (9.6–16.5) 17.2 (12.1–21.6) 0.018
 TC (mmol L−1) 4.86 (4.32–5.36) 4.90 (4.32–5.41) 0.428
 TG (mmol L−1) 1.89 (1.43–2.21) 1.88 (1.40–2.26) 0.501
 HDL-C (mmol L−1) 1.16 (1.03–1.24) 1.18 (1.05–1.29) 0.332
 LDL-C (mmol L−1) 2.48 (2.11–2.76) 2.40 (2.04–2.83) 0.242
 IL-6 (pg mL−1) 101.2 (76.5–138.6) 132.2 (102.3–164.8) 0.003
 HOMA-IR 2.13 (1.52–3.04) 2.20 (1.62–3.11) 0.151
 Serotonin (ng mL−1) 1.65 (0.39–3.83) 1.18 (0.35–2.96) < 0.001
 Irisin (ng mL−1) 120.3 (77.6–164.8) 74.2 (60.4–108.4) < 0.001
  1. Results are expressed as percentages for categorical variables and as medians (quartiles) for the continuous variables
  2. NIHSS National Institutes of Health Stroke Scale, mRS Modified Rankin Scale, S.D. standard deviation, IQR interquartile range, Hs-CRP high-sensitivity C-reactive protein, HCY homocysteine, BMI body mass index, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride, TC total cholesterol, HOMA-IR homeostatic model of assessment insulin resistance