Skip to main content

Table 2 Odds ratios for PSD according to irisin quartiles at admission

From: Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population

Irisin quartilesǂ


Unadjusted OR (95% CI)ξ

Adjusted OR (95% CI)*ξ

Q1, N = 301


9.01 (5.80–13.98)

4.85 (3.30–7.92)

Q2, N = 301


4.96 (3.19–7.73)

2.79 (1.82–4.37)

Q3, N = 301


3.28 (2.08–5.18)

1.82 (1.13–2.92)

Q4, N = 302




  1. OR odds ratio, CI confidence interval, PSD post-stroke depression, NIHSS National Institutes of Health Stroke Scale, mRS Modified Rankin Scale, Hs-CRP high-sensitivity C-reactive protein, HCY homocysteine, BMI body mass index, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride, TC total cholesterol, HOMA-IR homeostatic model of assessment insulin resistance, IL-6 interleukin-6
  2. ǂSerum levels of irisin in quartile 1 (< 71.1 ng/mL), quartile 2 (71.1–95.9 ng/mL), quartile 3 (96.0–144.0 ng/mL), and quartile 4 (> 144.0 ng/mL)
  3. *Adjusted for age, sex, BMI, stroke etiology, the NIHSS score, infarct volume, pre-stroke and acute treatment, vascular risk factors, mRS at follow-up, family history of psychiatric disorders, lesion location, living with offspring, widowhood, HOMA-IR, blood levels of glucose, Hs-CRP, HCY, IL-6, TG, TC, HDL, LDL, and serotonin and irisin quartiles
  4. ξP value for the trend < 0.001