Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population

Table 3 Serum irisin concentrations at admission prediction of PSD with AUROC

PSD	AUROC
PSD	Irisin	Risk factors^※	Risk factors with IRISIN^※	Incremental area (P)^‡	NRI (P)	IDI (P)
At admission	0.74	0.77	0.81	0.04 (0.02)	0.13 (0.003)	0.06 (0.01)

PSD post-stroke depression, NIHSS National Institutes of Health Stroke Scale, mRS Modified Rankin Scale, BMI body mass index, Hs-CRP high-sensitivity C-reactive protein, HCY homocysteine, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride, TC total cholesterol, HOMA-IR homeostatic model of assessment insulin resistance, IL-6 interleukin-6
^※Established risk factors including age, sex, BMI, stroke etiology, the NIHSS score, infarct volume, pre-stroke and acute treatment, vascular risk factors, mRS at follow-up, family history of psychiatric disorders, lesion location, living with offspring, widowhood, HOMA-IR, blood levels of glucose, Hs-CRP, HCY, IL-6, TG, TC, HDL, LDL, and serotonin
^‡Comparison of AUROCs: established risk factors without irisin levels vs. established risk factors with irisin levels

ISSN: 1742-2094