Fig. 5
From: Neuroinflammation is increased in the parietal cortex of atypical Alzheimer’s disease
Distribution of C3d and C4b differs between AD phenotypes. a In both typical and atypical AD, C1q deposition in the temporal cortex (blue border) is more diffuse than in the parietal cortex (burgundy border). b, c In typical AD, the temporal cortex shows more immunoreactivity for C3d and C4b than the parietal cortex. This distribution is inverted in atypical AD, showing more immunoreactivity for C3d and C4b in the parietal than temporal section. Bar represents 100 μm. d, e, and f Boxplots of immunoreactive area (%) for C1q, C3d, and C4b, respectively, in the temporal and parietal section of both AD phenotypes. Linear mixed model shows a different distribution for C3d and C4b over the 2 regions between phenotypes (#) (Table 5). *p < .0045