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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Neuroinflammation is increased in the parietal cortex of atypical Alzheimer’s disease

Fig. 6

Plaques in atypical AD show a different morphology compared to plaques in typical AD. ad In typical AD cases, the morphology of amyloid-beta (a for overview, b for detail) and C4b (c for overview, d for detail) deposits come in the form of diffuse, dense, or classical cored plaques. eh In atypical AD cases, amyloid-beta (e for overview, f for detail) and C4b (g for overview, h for detail) deposits show a distinct morphology, being coarse-grained and affecting a larger surface area (> 100 μm2) compared to classical cored plaques. Pictures are taken in the region with the highest number of amyloid-beta plaques, being temporal for typical AD and parietal for atypical AD (Fig. 2e). Bars represent 100 μm. i Boxplot of number of coarse-grained plaques quantified using C4b staining in the temporal and parietal cortex of typical and atypical AD. Linear mixed model shows a different distribution for coarse-grained plaques over the 2 regions between phenotypes (#) (Table 5). This distribution is parietally dominant in atypical AD. *p < .0045

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