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Table 2 Clinical and neuropathological characteristics of typical and atypical AD cases

From: Neuroinflammation is increased in the parietal cortex of atypical Alzheimer’s disease

Case Phenotype Symptoms at clinical presentation Sex Age at death Disease duration NFT stage [7] Amyloid stage [7] Brain weight (grams) Cause of death PMI ApoE
1 Typical AD Memory F 92 8 5 C 933 Heart failure 7:00 43
2 Typical AD Memory, disorientation F 84 4 4 C 908 Cardiogenic shock 4:15 32
3 Typical AD Memory, disorientation F 84 9 5 C 827 Cachexia 6:40 43
4 Typical AD Memory F 89 5 5 C 962 Pneumonia 6:28 43
5 Typical AD Memory F 83 6 6 C 1100 Dehydration 6:17 43
6 Typical AD Memory, behavior F 91 3 4 C 1026 Cachexia 6:25 33
7 Typical AD Memory, F 77 2 5 C 999 Pneumonia 6:05 33
8 Typical AD Memory, behavior M 70 2 6 C 1261 Metastasized colon carcinoma 6:20 43
9 Typical AD Memory F 76 12 5 C 1223 Unknown 10:45 44
10 Typical AD Memory M 60 2 6 C 1191 Cachexia 6:15 43
11 Atypical AD Aphasia, dyscalculia, agraphia, left-right agnosia, visuoconstruction problems F 65 6 6 C 975 Pneumonia 5:40 33
12 Atypical AD Aphasia, dyslexia, apraxia, visuoconstruction problems M 65 2 6 C 1057 Cardiac insufficiency 8:50 44
13 Atypical AD Aphasia, acalculia, fingeragnosia, apraxia M 64 7 5 C 1135 Pneumonia 4:45 42
14 Atypical AD Parkinsonism, falling, alien hand syndrome F 67 3 5 C 817 Epileptic insult 7:35 33
15 Atypical AD Aphasia, apathy, agitation M 59 6 6 C 1300 Cachexia 5:05 44
16 Atypical AD Aphasia, dyscalculia, dyslexia, disorientation M 62 3 6 C 1116 Malign neuroleptic syndrome 4:15 43
17 Atypical AD Aphasia, dyslexia, apathy, apraxia M 65 1 5 C 1150 Euthanasia 6:50 43
18 Atypical AD Aphasia, dyslexia, apraxia, visuospatial problems, behavior M 62 6 5 B 1153 Cachexia 4:40 33
19 Atypical AD Visual hallucinations, psychosis M 61 6 6 C 1355 Pneumonia 5:00 43
  1. Age at death and disease duration in years; post-mortem interval in hours to minutes. Typical AD defined as more neurofibrillary tangles in the temporal compared to the parietal cortex by semi-quantitative scoring as described by Hoogendijk et al. [27] and an amnestic presentation during life. Atypical AD defined as more neurofibrillary tangles assessed by semi-quantitative scoring in the parietal compared to the temporal cortex and a non-amnestic presentation
  2. AD Alzheimer’s disease, F female, M male, NFT neurofibrillary tangle, PMI post-mortem interval