Neuroinflammation is increased in the parietal cortex of atypical Alzheimer’s disease

Table 2 Clinical and neuropathological characteristics of typical and atypical AD cases

Case	Phenotype	Symptoms at clinical presentation	Sex	Age at death	Disease duration	NFT stage [7]	Amyloid stage [7]	Brain weight (grams)	Cause of death	PMI	ApoE
1	Typical AD	Memory	F	92	8	5	C	933	Heart failure	7:00	43
2	Typical AD	Memory, disorientation	F	84	4	4	C	908	Cardiogenic shock	4:15	32
3	Typical AD	Memory, disorientation	F	84	9	5	C	827	Cachexia	6:40	43
4	Typical AD	Memory	F	89	5	5	C	962	Pneumonia	6:28	43
5	Typical AD	Memory	F	83	6	6	C	1100	Dehydration	6:17	43
6	Typical AD	Memory, behavior	F	91	3	4	C	1026	Cachexia	6:25	33
7	Typical AD	Memory,	F	77	2	5	C	999	Pneumonia	6:05	33
8	Typical AD	Memory, behavior	M	70	2	6	C	1261	Metastasized colon carcinoma	6:20	43
9	Typical AD	Memory	F	76	12	5	C	1223	Unknown	10:45	44
10	Typical AD	Memory	M	60	2	6	C	1191	Cachexia	6:15	43
11	Atypical AD	Aphasia, dyscalculia, agraphia, left-right agnosia, visuoconstruction problems	F	65	6	6	C	975	Pneumonia	5:40	33
12	Atypical AD	Aphasia, dyslexia, apraxia, visuoconstruction problems	M	65	2	6	C	1057	Cardiac insufficiency	8:50	44
13	Atypical AD	Aphasia, acalculia, fingeragnosia, apraxia	M	64	7	5	C	1135	Pneumonia	4:45	42
14	Atypical AD	Parkinsonism, falling, alien hand syndrome	F	67	3	5	C	817	Epileptic insult	7:35	33
15	Atypical AD	Aphasia, apathy, agitation	M	59	6	6	C	1300	Cachexia	5:05	44
16	Atypical AD	Aphasia, dyscalculia, dyslexia, disorientation	M	62	3	6	C	1116	Malign neuroleptic syndrome	4:15	43
17	Atypical AD	Aphasia, dyslexia, apathy, apraxia	M	65	1	5	C	1150	Euthanasia	6:50	43
18	Atypical AD	Aphasia, dyslexia, apraxia, visuospatial problems, behavior	M	62	6	5	B	1153	Cachexia	4:40	33
19	Atypical AD	Visual hallucinations, psychosis	M	61	6	6	C	1355	Pneumonia	5:00	43

Age at death and disease duration in years; post-mortem interval in hours to minutes. Typical AD defined as more neurofibrillary tangles in the temporal compared to the parietal cortex by semi-quantitative scoring as described by Hoogendijk et al. [27] and an amnestic presentation during life. Atypical AD defined as more neurofibrillary tangles assessed by semi-quantitative scoring in the parietal compared to the temporal cortex and a non-amnestic presentation
AD Alzheimer’s disease, F female, M male, NFT neurofibrillary tangle, PMI post-mortem interval

ISSN: 1742-2094