Neuroinflammation is increased in the parietal cortex of atypical Alzheimer’s disease

Table 5 Results for the linear mixed model of transformed immunohistochemistry variables

Transformed variable	Fixed Effect	Phenotype	Results for linear mixed model
Transformed variable	Fixed Effect	Phenotype	Beta-coefficient	95% CI
pTau	Region x phenotype		1.53*	[1.33 – 1.72]
	Region	Typical AD	- 0.82*	[- 0.95 – - 0.68]
	Region	Atypical AD	0.71*	[0.57 – 0.85]
Amyloid-beta	Region x phenotype		0.04	[- 0.06 – 0.15]
Amyloid-beta	Region	Both	- 0.46*	[- 0.54 – - 0.39]
GFAP	Region x phenotype		1.25*	[1.02 – 1.48]
	Region	Typical AD	- 1.71*	[- 1.87 – - 1.56]
	Region	Atypical AD	- 0.46*	[- 0.63 – - 0.29]
Iba1	Region x phenotype		0.10	[0.002 – 0.19]
Iba1	Region	Both	- 0.47*	[- 0.53 – - 0.41]
CD68	Region x phenotype		- 0.43*	[0.38 – 0.48]
	Region	Typical AD	- 0.13*	[- 0.17 – - 0.10]
	Region	Atypical AD	0.29*	[0.26 – 0.33]
HLA-DP/DQ/DR	Region x phenotype		0.97*	[0.88 – 1.06]
	Region	Typical AD	- 0.08*	[- 0.14 – - 0.03]
	Region	Atypical AD	0.89*	[0.82 – 0.96]
C1q	Region x phenotype		- 0.05	[- 0.15 – 0.06]
C1q	Region	Both	0.03	[- 0.05 – 0.10]
C3d	Region x phenotype		0.74*	[0.62 – 0.86]
	Region	Typical AD	- 0.39*	[ - 0.47 – - 0.31]
	Region	Atypical AD	0.36*	[0.26 – 0.45]
C4b	Region x phenotype		0.95*	[0.84 – 1.07]
	Region	Typical AD	- 0.24*	[- 0.32 – - 0.17]
	Region	Atypical AD	0.71*	[0.62 – 0.80]
# of amyloid-beta plaques	Region x phenotype		0.58*	[0.41 – 0.75]
	Region	Typical AD	- 0.33*	[- 0.44 – - 0.21]
	Region	Atypical AD	0.25*	[0.13 – 0.37]
# of C4b plaques	Region x phenotype		1.84*	[1.58 – 2.11]
	Region	Typical AD	- 0.39*	[- 0.56 – - 0.22]
	Region	Atypical AD	1.46*	[1.25 – 1.66]

Results of the linear mixed model for analyzed immunohistochemistry variables are shown. All variables were transformed: ln(variable + 1). We tested if the distribution over the 2 regions was different between the 2 AD phenotypes, defined as the interaction effect: region × phenotype. When an interaction effect was found, the beta-coefficient is shown per phenotype. To correct for multiple testing, a p value < .0045 was considered significant (p < .05/11 outcome measurements) and indicated with *
AD Alzheimer’s disease, CI confidence interval
# Number

ISSN: 1742-2094