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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson’s disease

Fig. 2

Treatment of regionally isolated microglia with the Parkinson’s toxin MPP+ causes differential upregulation of cytokines. Regionally isolated microglia were collected and exposed to the PD toxin MPP+ for 24 h. After toxin exposure, microglia were examined for expression of pro- and anti-inflammatory cytokines in comparison to untreated region-specific controls. MPP+-treated SN microglia (left column) exhibit a greater degree of pro-inflammatory cytokine upregulation, including IL1β, IL12α, CCL3, CCL4, CCL19, IL1α, and TNFα, coupled with significant downregulation of IFNγ compared to untreated control SN microglia. VTA microglia (middle column) share upregulation of pro-inflammatory IL1β, CCL3, CCL4, and TNFα similar to SN microglia. However, they exhibit higher levels of IL3, as well as the anti-inflammatory cytokines IL4, IL13, and IL6. Interestingly, CTX lack upregulation of IL1β and IL12α, whereas they demonstrate strong expression of TNFα

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Journal of Neuroinflammation

ISSN: 1742-2094