Fig. 2
From: Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
Single administration of PC attenuated CCI-induced neuropathic pain and suppressed CCI-induced activation of MMP-9/2 in vivo. a Single administration of PC (15, 30, 90 mg/kg, p.o.) at 14 days after CCI injury significantly attenuated CCI-induced mechanical allodynia (n = 6). b–d PC (15, 30, 90 mg/kg, p.o.) decreased the activity of MMP-9/2 in the spinal cords in a dose-dependent manner. The lumbar spines (L1–L6) were collected and analyzed 120 min after the drug administration. Representative bands and a data summary (n = 4) were shown. Significant difference was revealed following one-way or two-way ANOVA (**P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. CCI group; Bonferroni post hoc tests)