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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2

Fig. 4

PC significantly attenuated CCI-induced neuron cells’ activation and interleukin (IL)-1β production in spinal cords. a, b Consecutive administration of PC significantly inhibited the cleavage of IL-1β but did not affect the production of pro-IL-1β. PC (90 mg/kg, p.o.) was administered daily from day 14 to day 20 after CCI operation. (80 μg of proteins were loaded when western blot was performed). cf Single administration of PC inhibited CCI-induced phosphorylation of protein kinase C (PKC)γ and N-methyl-d-aspartate receptor (NR)1. PC (90 mg/kg, p.o.) was administered at day 14 after CCI operation. The lumbar spines (L1–L6) were collected and analyzed 120 min after the last administration. Significant difference was revealed following one-way or two-way ANOVA (*P < 0.05, **P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. CCI group; Bonferroni post hoc tests)

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