Fig. 5
From: Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
PC significantly inhibited CCI-induced activation of microglia marker IBA-1. a, b PC (90 mg/kg, p.o.) significantly decreased the expression of IBA-1 in the spinal cords. c, d Confocal images and immunofluorescence analysis data showing IBA-1 in the dorsal horns. PC (90 mg/kg, p.o.) significantly decreased IBA-1 expression in the spinal cords. Quantification of immunofluorescence was represented as mean fluorescence pixels in the superficial dorsal horns (n = 3, 5 images per animal). PC (90 mg/kg, p.o.) was consecutively administrated daily from day 14 to day 20 after CCI operation. The lumbar spines (L1–L6) were collected and analyzed 120 min after the last drug administration. Significant difference was revealed following one-way ANOVA (**P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. CCI group; Bonferroni post hoc tests)