Fig. 6
From: Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
PC suppressed LPS-induced microglia activation by inhibiting p38 MAPK/NF-κB. a, b Pre-administration (15 min) of PC (25, 50, 100 μM) significantly inhibited the phosphorylation of p38 MAPK after LPS treatment for 2 h in a dose-dependent manner. Representative western blot bands and a data summary (n = 4) for p-p38 and p38 are shown. c, d PC (100 μM) inhibited the NF-κB translocation from the cytosol to the nucleus after LPS treatment for 4 h in BV-2 cells. e MTT experiments showed that different doses of procyanidins did not affect cell proliferation. Significant difference was revealed following one-way or two-way ANOVA (*P < 0.05, **P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. LPS-treated group; Bonferroni post hoc tests; scale bar 10 μm)