Fig. 3

CD73 deficiency exacerbated the motor dysfunction, inflammatory responses, and neuronal apoptosis induced by SCI. a Degree of motor disturbance assessed by the Basso, Beattie, and Bresnahan (BBB) criteria at different time points after SCI or sham surgery of wild-type (WT) or CD73 knock out (KO) mice. b–e Relative mRNA expression of TNF-α, IL-1β, IL-6, and Caspase 3 on the third day after SCI or sham surgery in two groups. f, g Representative hematoxylin-eosin (HE) and Nissl staining of different groups 3 days after SCI or sham surgery. h–k Immunopositive particles for TNF-α and IL-1β and quantification 3 days post-injury or sham surgery in WT or CD73 KO mice. l, m Representative Western blotting and statistical comparison of Caspase 3 on the third day after SCI or sham surgery in WT or CD73-deficient mice. **p < 0.01, ***p < 0.001. Data are shown as the mean ± SD from four independent experiments