Fig. 8
CD73 augments microglial M2 polarization via A2B adenosine receptor activation. a, b The mRNA expression of microglial M1/M2 markers in BV2 cells challenged with LPS/IL-4 in presence or absence of siRNA or NECA. *p < 0.05, **p < 0.01, ***p < 0.001. c, d The mRNA expression of microglial M1/M2 markers in BV2 cells challenged with LPS/IL-4 in presence or absence of pcDNA3.1 or MRS1706. *p < 0.05, **p < 0.01, ***p < 0.001. e–h The iNOS/Arg1 protein expression in BV2 cells challenged with LPS/IL-4 in presence or absence of siRNA or NECA and statistical comparison. **p < 0.01 versus LPS/IL-4, #p < 0.05, ##p < 0.01, ###p < 0.001 versus LPS/IL-4 + siRNA. i–l The iNOS/Arg1 protein expression in BV2 cells challenged with LPS/IL-4 in presence or absence of pcDNA3.1 or MRS1706 and statistical comparison. **p < 0.01, ***p < 0.001 versus LPS/IL-4, #p < 0.05, ##p < 0.01, ###p < 0.001 versus LPS/IL-4 + pcDNA3.1. Data are shown as the mean ± SD from four independent experiments