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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation

Fig. 6

DPI post-treatment attenuated microglia activation in brain after LPS injection. a Wild-type mice were treated with a single dose of 0.01, 0.1, or 1 mg/kg DPI or vehicle (0.025% DMSO) 30 min after 4 mg/kg LPS injection (i.p.), and then sacrificed 24 h after LPS. Brain sections were prepared and immunostained for the microglial marker iba-1. Representative images of the stained microglia in the dentate gyrus (DG) and CA3 regions of mouse hippocampus are shown. b Activated microglia were identified by increased cell size and irregular shape. The proportions of activated microglia in hippocampus were estimated. Data represent the mean ± SEM of values from three animals per treatment. Bonferroni post hoc test vs. vehicle-treated mouse group; *p < 0.05, **p < 0.01, ***p < 0.001

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