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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: NADPH oxidases as potential pharmacological targets against increased seizure susceptibility after systemic inflammation

Fig. 7

DPI post-treatment attenuated pro-convulsive cytokine expression in brain after LPS injection. Wild-type mice were treated with a single dose of vehicle or DPI at 0.01, 0.1, or 1 mg/kg 30 min after LPS injection. The brains were harvested for assessment of the transcript expression (n = 5/group) of several cytokines using RT-qPCR (a–d) 1.5 h after LPS injection, and the protein levels (n = 3/group) using multiplex assay 24 h after LPS injection (e–h), respectively. β-actin expression served as the internal control. The expression of each cytokine of the DPI-treated mice was compared with that of the LPS-injected vehicle-treated control. Data present the mean ± SEM. Bonferroni post hoc test vs. LPS-injected vehicle-treated group; *p < 0.05, **p < 0.01

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