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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Molecular and clinical characterization of PTPN2 expression from RNA-seq data of 996 brain gliomas

Fig. 5

PTPN2-related inflammatory response. a, b Heat maps displaying the clinicopathological parameters, PTPN2 expression, and seven related metagenes from the CGGA and TCGA datasets. As shown, PTPN2 expression positively correlates with HCK, LCK, MHC II, and STAT1 gene expression but is negatively related to IgG. c, d Correlograms were established based on the relationship between PTPN2 expression and GSVA enrichment scores for these seven metagenes. PTPN2 expression is positively correlated with HCK, LCK, MHC II, and STAT1 in the CGGA and TCGA cohorts but negatively correlated with IgG and interferon. The circles were filled in blue clockwise for positive values and in red anticlockwise for negative values. The intensity of color increases with the correlation value moving away from 0

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