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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Splenic responses play an important role in remote ischemic preconditioning-mediated neuroprotection against stroke

Fig. 3

The effect of RIPC on splenic volume and lymphocyte populations followed by MCAO. a Experimental protocols. RIPC was conducted 1 h before MCAO. Non-RIPC animals were exposed to the same anesthesia for 40 min. Brain ischemia was induced by 90 min MCAO. Sham-operated animals underwent anesthesia and surgical exposure of the right middle cerebral artery without occlusion. Three groups of animals were prepared: RIPCMCAO, RIPCMCAO+, and RIPC+MCAO+. b Representative spleen images from each group. c Spleen weight of rats in each group. dg Quantification of the number of different splenic lymphocytes. Data are expressed as fold change of control group (RIPCMCAO). n = 8 rats per group. Data are presented as means ± SEM, *p < 0.05, **p < 0.01 versus RIPCMCAO rats, #p < 0.05, ##p < 0.01 versus RIPCMCAO+ rats

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