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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Splenic responses play an important role in remote ischemic preconditioning-mediated neuroprotection against stroke

Fig. 7

The effect of RIPC and splenectomy on immune cell infiltration into the ischemic brains. Three groups of animals were prepared: MCAO, RIPC + MCAO, and Sp-RIPC + MCAO (n = 6 per group). Splenectomy was conducted 1 day before 40 min RIPC and 90 min MCAO. Non-splenectomy animals underwent anesthesia and surgical exposure of the spleen without removal. The brains were collected at 3 days after MCAO. a, c, e, g Representative plots of FACS showing Th, Tc, NKT, and B cells in contralateral and ipsilateral hemispheres. Indicated numbers are the mean percentages of targeted cells. b, d, f, h Statistical analysis of different lymphocyte populations in contralateral and ipsilateral hemispheres. Data are normalized to the mean of respective contralateral brains and presented as means ± SEM, *p < 0.05, **p < 0.01 versus corresponding lymphocytes in contralateral hemispheres

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