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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

Fig. 4

VPA inhibits HDAC3 expression in the lesioned spinal cord. a Western blot analysis demonstrated that the expressions of HDAC 1–3 were expressed at a low level in the sham group, but were upregulated in the lesioned spinal cord 7 days after the SCI. The VPA treatment reduced the HDAC3 protein expression more than the SCI group (P < 0.05), without affecting the HDAC1 and the HDAC2 protein expressions (P > 0.05). b The HDAC3 activity in the SCI + VPA group was significantly less than in the SCI group (P < 0.05). c The expressions of HDAC3 in the cytosol, nuclei, and in total protein levels of the cells from the lesioned cortices increased after the SCI. The VPA treatment effectively decreased the HDAC3 expression in the nuclear and in the total protein of cells from the lesioned spinal cord (P < 0.05) but not in the cytosol protein (P > 0.05). Values were expressed as mean ± standard deviation (n = 6 per group). N.S., P > 0.05, *P < 0.05, **P < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094