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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

Fig. 5

HDAC3 expression was inhibited in both neurons and microglia after VPA treatment. Double immunohistochemical staining was used to assess the neuron (NeuN+) and the microglia (Iba-1+) in the lesioned spinal cord 7 days after the SCI. a The SCI enhanced the expression of the HDAC3 in neurons (NeuN+), which significantly decreased after the VPA treatment. Representative photomicrographs of the HDAC3-positive neurons are shown. Enlarged images of boxed areas are shown on the right. b The SCI enhanced the expression of HDAC3 in microglia (Iba-1+), which was significantly decreased following the VPA treatment. Representative photomicrographs of HDAC3-positive microglia are shown. Enlarged images of boxed areas are shown on the right. Scale bars = 50 μm

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