Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Aquaporin-4 deletion ameliorates hypoglycemia-induced BBB permeability by inhibiting inflammatory responses

Fig. 3

AQP4 deletion decreased inflammatory responses by upregulating the PPAR-γ signaling pathways during hypoglycemic stress. a The fold change of mRNA expression of TNF-α. b The fold change of mRNA expression of IL-1β. c The fold change of mRNA expression of IL-6. The expression levels and mRNA of TNF-α, IL-1β, and IL-6 were significantly increased in the Hypo group compared to the WT group; however, they were significantly reduced in the AQP4−/− + Hypo group compared to the Hypo group. d ELISA analysis of TNF-α proteins in the cerebral cortex from mice. e ELISA analysis of IL-1β proteins in the cerebral cortex from mice. f ELISA analysis of IL-6 proteins in the cerebral cortex from mice. g Western blot analysis of PPAR-γ protein expression. h Quantitative analysis of PPAR-γ protein expression. i The mRNA expression of PPAR-γ in the brains of mice subjected to hypoglycemia. *P < 0.05 or **P < 0.01 vs. the WT group, #p < 0.05 or ##p < 0.01 vs. the Hypo group. n = 3 in each group

Back to article page