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Table 1 List of proteins identified in control EV samples

From: Inflammation leads to distinct populations of extracellular vesicles from microglia

Protein ID

Gene name

Protein name

Score

P08226

APOE

Apolipoprotein E

506

P21956

MFGE8

Lactadherin

136

P21460

CST3

Cystatin-C

123

Q9WU78

PDCD6IP

Programmed cell death 6-interacting protein

121

P11152

LPL

Lipoprotein lipase

107

Q8VDN2

ATP1A1

Sodium/potassium-transporting ATPase subunit alpha-1

105

P62737

ACTA2

Actin, aortic smooth muscle

84

Q61753

PHGDH

D-3-phosphoglycerate dehydrogenase

80

P07901

HSP90AA1

Heat shock protein HSP 90-alpha

80

P10605

CTSB

Cathepsin B

75

P01942

HBA

Hemoglobin subunit alpha

73

P63017

HSPA8

Heat shock protein 8

71

Q62419

SH3GL1

Endophilin-A2

70

Q8R366

IGSF8

Immunoglobulin superfamily member 8

69

Q68FD5

CLTC

Clathrin heavy chain 1

67

P10923

SPP1

Osteopontin

64

Q61207

PSAP

Prosaposin

64

P06869

PLAU

Urokinase-type plasminogen activator

62

Q8CGP5

HIST1H2AF

Histone H2A type 1-F

61

P52480

PKM

Pyruvate kinase

59

P17182

ENO1

Alpha-enolase

56

P04104

KRT1

Keratin, type II cytoskeletal 1

50

P68369

TUBA1A

Tubulin alpha-1A chain

47

P01887

B2M

Beta-2-microglobulin

45

P09405

NCL

Nucleolin

44

P09055

ITGB1

Integrin beta-1

42

P01901

H2-K1

H-2 class I histocompatibility antigen, K-B alpha chain

41

P01899

H2-D1

H-2 class I histocompatibility antigen, D-B alpha chain

36

P29341

PABPC1

Polyadenylate-binding protein 1

41

P06797

CTSL

Cathepsin L1

38

P10852

SLC3A2

4F2 cell-surface antigen heavy chain

37

P08905

LYZ2

Lysozyme C-2

34

P10126

EEF1A1

Elongation factor 1-alpha 1

28

Q61937

NPM1

Nucleophosmin

27

Q9DBJ1

PGAM1

Phosphoglycerate mutase 1

25

P28798

GRN

Granulins

24

P14206

RPSA

40S ribosomal protein SA

24

  1. Proteins retrieved in control extracellular vesicle samples from mass spectrometry. Protein ID and gene name are according to Uniprot Knowledgebase. Score values were obtained using MASCOT. The Score shows how well the observed protein matches to the stated protein in the database. Only protein identifications supported by at least two high confident peptides (confidence > 95%) were considered