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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Serum amyloid A primes microglia for ATP-dependent interleukin-1β release

Fig. 7

Treatment of rat cortical microglia with Apo-SAA, in a time-dependent manner, upregulates mRNA for TLR2 and downregulates that for TLR4. Cultures were treated the day after plating with 0.5 μg/ml recombinant human Apo-SAA and processed 1, 3, 6, and 24 h later for q-PCR, as detailed in the “Methods” section. a TLR2. b TLR4. Data are presented as relative expression level (normalized with respect to β-actin (βACT)) at each time point and are mean ± sem, n = 3 (n = 9 for 3 h). Control (CTRL; untreated) cultures. ***p < 0.001 vs CTRL for that time point; °°°p < 0.001 vs CTRL for that time point. Note the difference in expression levels between TLR2 and TLR4 mRNA

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