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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats

Fig. 6

The effect of Aggf1 siRNA on neurological functions, brain water content, BBB permeability, and inflammatory response at 24 h after subarachnoid hemorrhage (SAH). a The expression of Aggf1 was significantly reduced in the ipsilateral cortex by Aggf1 siRNA at 24 h after SAH. $P < 0.05 vs Scr siRNA. b–e Knockdown of Aggf1 using Aggf1 siRNA aggravated neurological impairments and increased brain edema and EB extravasation and MPO expression at 24 h following SAH. #P < 0.05 vs sham; *P < 0.05 vs vehicle; @P < 0.05 vs vehicle, rh-Aggf1, and Scr siRNA. EB, Evans blue; MPO, myeloperoxidase; Scr siRNA, scrambled siRNA

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Journal of Neuroinflammation

ISSN: 1742-2094