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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats

Fig. 9

LY294002 reversed the neuroprotection of exogenous Aggf1 after subarachnoid hemorrhage (SAH). a Pretreatment of LY294002 abolished the protective effects of rh-Aggf1 on neurological functions. be LY294002 reversed the effects of rh-Aggf1 against brain edema and BBB permeability and inflammatory response (albumin extravasation and MPO expression). c, fl LY294002 reserved rh-Aggf1 induced changes in protein levels of PI3K, p-Akt, p-NF-κB p65, VE-cadherin, Occludin, claudin-5, TNF-α, and IL-1β in rh-Aggf1-treated rats after SAH. #P < 0.05 vs sham; *P < 0.05 vs vehicle; &P < 0.05 vs rh-Aggf1 and rh-Aggf1+DMSO. DMSO, dimethyl sulfoxide; LY294002, PI3K-specific inhibitor; MPO, myeloperoxidase

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