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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: In utero electroporation induces cell death and alters embryonic microglia morphology and expression signatures in the developing hypothalamus

Fig. 1

Altered microglia morphology following in utero electroporation. Expression of Iba1 in E15.5 wild-type (a, a’, c, d) and E15.5 pCIG2 IUE (E14.5) brains (b, b’, e, f) demonstrate an increase in the number of Iba1+ amoeboid cells lining the third ventricle of IUE brains. 3V, third ventricle. Dashed lines outline the ventricle and mark the division between the thalamus and hypothalamus. White arrows mark Iba1+ microglial projections. Scale bar represents 100 μm (a–f). g Quantification of Iba1+ cells within the third ventricle shows an increase in the number of Iba1+ cells in IUE brains as compared to wild-type brains (mean ± SEM; wild-type n = 3, IUE n = 3; p < 0.0001)

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Journal of Neuroinflammation

ISSN: 1742-2094