Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway

Fig. 1

Expression of miRNA-146a-5p in rat DRG and SDH after CCI. a, b CCI-induced mechanical allodynia and thermal hyperalgesia manifested as a lowered threshold of mechanical withdrawal (a) and thermal withdrawal (b). Eight rats were included in each group. Two-way ANOVA, *P < 0.05, versus sham. c qPCR showing the time course for miRNA-146a-5p level in DRG (n = 4 in each group). One-way ANOVA, *P < 0.05, versus sham. d, e FISH showing expression and distribution of miRNA-146a-5p in rat DRGs of sham (d) and CCI 14 days (e). Scale bar 50 μm. f qPCR showing the time course for miRNA-146a-5p level in SDH (n = 4 in each group). One-way ANOVA, *P < 0.05, versus sham. g, h FISH showing expression and distribution of miRNA-146a-5p in rat SDH of CCI 7 days (g) and CCI 14 days (h)

Back to article page