Fig. 2

Dysregulation of complement components in the lumbar spinal cord of TDP-43^Q331K mice at three different ages of disease progression. a–f The mRNA expression profiles of the following complement components: C1qB (a, classical pathway), C4 (b, classical/lectin pathway), fB (c, alternative pathway), C3 (d, central component), CD55 (e, regulator) and CD59a (f, regulator) in the lumbar spinal cord of TDP-43^Q331K mice (blue bars) relative to non-transgenic (NTg, orange bars) and TDP-43^WT (green bars) mice during 3, 10 and 16 months of age. Data are expressed as means ± SEM (n = 5 mice/group, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, one-way ANOVA with Tukey’s post hoc test)